The AV 2025 APEX 50

Companies we are proud to own.

Apex 50
Written by

Alumni Ventures

Published on

Read

5 min

We are pleased to announce our AV 2025 Apex 50. This selection of 50 ventures from Alumni Ventures’ portfolio of over 1,500 current and historical investments represents some of the names we’re most excited about heading into 2025. These companies were selected for their innovative impact, outstanding performance, and potential upside.

As one of the most active venture capital firms globally, AV routinely co-invests alongside top lead investors, helping to ensure our portfolio reflects high-caliber opportunities. We’re proud to back stellar companies such as Groq, Rigetti, Lambda, Oura, and Bluesky. Please explore the Apex 50 list of amazing ventures in sectors ranging from next-generation nuclear power to quantum computers, AI-driven drug discovery, space logistics, brain-computer interfaces, fusion technology, AI hardware, cloud storage, blockchain analytics, defense tech, and more.

The AV 2025 APEX 50

Circle

Enables businesses to use digital currencies

  • Market leader in stablecoins; best known for USD Coin

Co-investor: Sequoia

HawkEye 360

Operates a satellite constellation that collects RF signals

  • Awarded $12.25M by U.S. government
  • Space Flight Laboratory recently confirmed deployment of satellites

Co-investor: Insight Partners

Oura

Captures and optimizes personalized biometric data

  • Partners with brands such as NBA, Equinox

Co-investor: Gradient Ventures

Bluesky

Decentralized social media platform offering greater data control

  • User base rose 763% in 2024
  • Customizable algorithms, and an open ecosystem to foster transparency

Co-investor: Bain Capital

Pacific Fusion

Redefining fusion energy landscape

  • Aims to deliver affordable, clean energy

Co-investor: General Catalyst

Lambda

AI infrastructure company

  • Recognized four years in a row as NVIDIA Partner of the Year

Co-investor: Gradient Ventures

Enable

Provider of rebate solutions

  • Manages, tracks, and analyzes rebates more efficiently, from agreement to payment

Co-investor: Menlo Ventures

Groq

Cutting-edge AI hardware startup

  • Partnerships with industry leaders
  • Top clients in cloud computing, healthcare, autonomous vehicles

Co-investor: BlackRock

RapidSOS

Tech company enhancing emergency response

  • Provides real-time, data-driven insights to first responders
  • Integrates data from devices and sensors to deliver actionable information

Co-investor: BlackRock

Wasabi

Provides hot cloud storage

  • Competes against Amazon’s S3 cloud storage while performing at 6x speeds and 1/5th the price
  • Led by a seven-time founder

Co-investor: Fidelity Investments

Sleeper

Transforming fantasy sports

  • Over 5 million monthly active users
  • Launched “Sleeper Media”

Co-investor: Andreessen Horowitz

SHINE Technologies

Revolutionizing medical isotope production

  • Generating critical materials for cancer treatment and medical imaging
  • Roadmap transitions from medical isotopes to nuclear waste transmutation, then fusion power generation
  • Already producing 100,000 doses annually of cancer-fighting lutetium-177

Co-investor: Oaktree Capital

Pendulum

Microbiome therapies for metabolic diseases

  • Targeted formulations of natural bacterial strains help to rebalance the microbiome to restores and improve health

Co-investor: Sequoia Capital

Yassir

Rapidly expanding “super-app”

  • Provides on-demand services such as ride-hailing, delivery, and financial solutions across North Africa and other emerging markets
  • 8M+ app downloads and 2M monthly active users

Co-investor: Y Combinator

Honor

Software to improve in-home senior care

  • Exceptional revenue growth
  • Proven management team

Co-investor: Andreessen Horowitz

SonderMind

Mental health access through AI-driven tools

  • Scaling rapidly while delivering innovative mental health solutions
  • $77B+ market size

Co-investor: General Catalyst

Kraken

Leading crypto exchange

  • Ranked as #1 crypto exchange by Forbes

Co-investor: 2B Global

Lincode

AI-based platform for manufacturing quality inspection

  • Secured contracts with multinational partners, including BMW, Honda, Scheider, Tata, and aerospace giant Boeing

Co-investor: Accel

Unstructured

AI-driven platform that turns unstructured data into actionable
insights

  • Fast Company’s Most Innovative Company (2024) and Forbes AI 50
  • Adoption by Fortune 500 companies; used by 50K companies

Co-investor: Bain Capital, Menlo Ventures

Kapital

Modernizing financial services for Latin American SMBs

  • Combines access to capital with powerful business management tools
  • Serving over 90,000 customers

Co-investor: Tribe Capital

Axiom Space

Private space flights and missions

  • Building the first commercial successor to the ISS, democratizing space access for space agencies and nations, while enabling corporate R&D, manufacturing, and space tourism 
  • Billions in secured contracts

Co-investor: Prime Movers Lab

Enfabrica

Chip and cloud optimization

  • Designs networking chips, systems, and software for AI computing
  • Helps AI chips work more efficiently

Co-investor: Spark Capital, NVIDIA

Method

Provides tools that give fintechs and lenders seamless access to consumer credit and debt accounts

  • Offers customers frictionless debt repayment options directly in apps
  • Has helped 200,000+ users connect $22 billion

Co-investor: Andreessen Horowitz

Cents

Vertical SaaS platform for laundry operators

  • Partnerships with Uber, DoorDash, and residential operators
  • Minimal churn

Co-investor: Tiger Global

Unlearn

Leveraging AI to accelerate drug development

  • Creates “digital twins” — virtual patients that can simulate treatment responses and predict clinical outcomes
  • Used for research into Alzheimer’s, ALS, and more

Co-investor: 8VC, DCVC

Precision

Developer of AI-powered brain-computer interfaces

  • Validated in large-animal studies
  • In-human trial approval expected in 2025

Co-investor: B Capital

Forta Health

Family-powered autism support

  • Transforming adolescent and family mental health care
  • Contracted with seven of the top 10 largest U.S. health insurers

Co-investor: Insight Partners

Synchron

Developer of brain-computer interfaces

  • Designed to restore motor function in individuals
  • Significant strides in clinical trials

Co-investor: Khosla Ventures

X-Energy

Leads next-gen nuclear power

  • Collaborating with major players like Amazon, Dow, Ontario Power
  • Pipeline of 50+ customers from public and private sectors

Co-investor: Amazon, Citadel

Iambic

AI-driven biotech and drug design

  • Address complex drug design challenges
  • Platform has outperformed Google’s AlphaFold

Co-investor: Sequoia Capital

Atom Computing

Developer of large-scale quantum computers

  • Using atomic arrays of optically-trapped neutral atoms
  • Considered the first to reach the 1,000-qubit milestone

Co-investor: Google Ventures

Fleet

Mineral exploration via satellite

  • Mineral exploration solution that combines satellite connectivity, 3D imaging, and AI 
  • Also generating substantial revenue from defense

Co-investor: Horizon Ventures

Centaur Health

Revolutionizing radiotherapy

  • Secured millions in orders from leading cancer centers
  • Received regulatory clearance

Co-investor: Deerfield Partners

TRM Labs

Market leader in blockchain analytics

  • Helping detect and mitigate risks
  • Adoption by PayPal, Visa, and FBI to name a few

Co-investor: Bessemer Venture Partners

Impulse Space

Pioneering in-space transportation market

  • Solutions for satellite deployment and orbit transfers
  • Significant government, commercial contracts, and
    partnerships (DOD, Vast, Anduril)

Co-investor: Founders Fund

Surge

Groundbreaking drug delivery platform

  • Partnerships across leading oncology centers
  • Enables precise targeting of solid tumors, using localized drug release to minimize side effects and maximize efficacy

Co-investor: Khosla Ventures

Opus Clip

AI-powered video editing platform

  • Supporting over 6 million creators and businesses
  • Combines ease of use, superior products, and growing data moat

Co-investor: DCM Ventures, Millennium New Horizons, Samsung Nex

HaydenAI

AI-enhanced traffic management

  • Proprietary technology, protected by multiple patents
  • Proven execution in the U.S. market and expanding internationally

Co-investor: TPGNVIDIA

Nixtla

Forecasting & anomaly detection tools

  • Flagship product trained on over 100 billion data points
  • Reduces uncertainty and enables data-driven decision-making across industries, including financial, weather, energy, and web data

Co-investor: True Ventures, Microsoft

Cohere

Advanced language models and natural language processing tools

  • Founder’s 2017 research paper helped launch LLM revolution
  • Partnering with Palantir

Co-investor: NVIDIA

Altera

AI characters for gaming

  • Partnered with major gaming studios and Open AI
  • Unveiled an agent capable of playing Minecraft

Co-investor: Andreesen Horowitz

Babylon

Integrates Bitcoin directly into proof-of-stake blockchains

  • Supports over $5B in staked Bitcoin
  • Robust security and liquidity infrastructure for Web3 ecosystem

Co-investor: Paradigm

Xanadu

Quantum computing developer leveraging photonics-based hardware

  • Partnering with AWS, BMW, IBM, NVIDIA, CERN and others
  • Board members include 14-time Midas List investor

Co-investor: Bessemer

Sahara

Decentralized AI blockchain platform

  • Enables freely and securely deploying autonomous AI with a high-performance, privacy-first network
  • Addressing complex copyright and privacy concerns tied to AI

Co-investor: Pantera Capital

Railway

Intuitive platform that automates infrastructure management

  • Scaled to 50,000+ developers; launched 900K+ projects
  • Intuitive platform automates infrastructure management and eliminates the need for deep DevOps expertise

Co-investor: Redpoint Ventures

Frore Systems

World’s first solid-state active cooling chip for personal devices

  • Awarded CES 2023 Best in Show
  • Board includes 15x Midas List investor

Co-investor: Fidelity

Rwazi

AI-powered market intelligence in emerging markets

  • Scaled revenue 6x in 24 months
  • Customers include Red Bull, Nestle, and Estee Lauder

Co-investor: Bonfire Ventures

Ascend Elements

Proprietary recycling process for lithium-ion EV batteries

  • Recovers / reuses cathode materials
  • Plans to produce >99% pure, sustainable lithium carbonate from used lithium-ion batteries

Co-investor: BlackRock

Mysten Labs

Cutting-edge Layer 1 technology

  • Offers high scalability, low latency, and cost efficiency
  • Releasing Web 3 gaming device in 2025

Co-investor: Binance Labs

Rigetti

Superconducting quantum integrated circuits

  • Also building software to integrate quantum computing into existing cloud infrastructure

Co-investor: Y Combinator


Download The AV 2025 Apex 50 to explore the full list of ventures and learn more about their groundbreaking work.

America’s Largest VC Firm for Individual Investors

No representation is intended that any investment or outcome shown is or would be representative of any AV fund or the outcomes experienced by any AV investor.  The Apex 50 portfolio companies are provided for illustrative purposes only, and are not available to future investors except potentially in the case of follow-on investment.  Venture capital investing involves substantial risk, including risk of loss of all capital invested.  This communication is neither an offer to sell, nor a solicitation of an offer to purchase, any security.  Such offers are made only pursuant to the formal offering documents for the fund, which describe the risks, terms, and other information that must be carefully considered before an investment is made.

Frequently Asked Questions

FAQ
  • Speaker 1:
    Hello, I’m Mike Collins. I’m the founder and CEO of Alumni Ventures. Today we’re going to go over our 2025 Apex 50—telling people a little bit about some of the companies within our portfolio that we’re excited to be a part of, and I think it points to the future and where a lot of technology and innovation is going. So looking forward to telling you a little bit about how we put together the list today. Just a quick disclosure: this reflects our opinions. This is not an offer to buy or sell any securities. Consult your investing professionals.

    Okay? Just very quickly, I think most of you know me—grew up in the Midwest, been in the business since the eighties. Really, my love is at the intersection of technology, innovation, entrepreneurship, and venture capital. I started the business to bring venture capital to retail investors in a smart, simple, entertaining, lucrative way. We’ve been successful. We’ve raised 1.5 billion. Of note, I think we are one of the more active venture capital firms in the world. We have a very large portfolio, and I think we have built a reputation of being a very strong co-investor to really try and help our entrepreneurs the best we can.

    We have a large and growing trophy case. Again, we stick to our lane. I don’t think we overpromise, and again, we’re extremely focused on serving our customers and serving our portfolio companies. So hopping right in—what is the Apex 50? From our entire portfolio, we basically ask our teams to nominate companies. We think by highlighting a small fraction of them—kind of less than 5%—it actually brings it to life for people. The sheer volume of the companies we’re involved with can just, I think, overwhelm people. So narrowing it down so it’s something people can pursue and study. Because we’re such a leading co-investor, I think it also points to where top-tier venture capital firms are investing. Obviously, a lot of these firms are beyond the seed stage, but I think it’s very interesting to look at the diversity.

    This is a pretty interesting cross-section. Again, there’s already a lot in data and software, but I think it shows that the venture industry is really diverse—and so is our portfolio. Why does it matter? I think it really points to where the companies that you’re going to be hearing about in five or ten years come from—the garages and apartments of small teams today. As I mentioned, I think it really points to the areas where VCs are allocating capital. I think there is a lot of focus today in a very narrow subset. A lot of it’s related to AI and what’s going on with OpenAI and Google and Meta, but the breadth and depth of the entrepreneurial ecosystem in the United States, I think, sometimes is underappreciated. So the diversity of these companies, I think, is important to underscore.

    I also think it’s really—entrepreneurship, venture capital, innovation—that creates enormous value for our society. We are always dealing with problems, unintended consequences, sometimes caused by previous technologies, but I think it is very important that we continue to inspire entrepreneurship. Clearly, this is the engine that drives the capitalist economy. If you look at the value that has been created—really within the stock market—if you look at the leading companies, most of those are venture-backed companies, creating jobs, providing solutions, and it is always about moving forward. This is a case where today’s technology solves a problem, creates unintended consequences, creates new problems that again, have to be solved. So just three companies here within the AV portfolio working in the area of defense and security—in the case of Hawkeye 360; Yassir serving kind of a super app, providing value to consumers in Africa; and then we’ve got picks and shovels in the area of AI and computing. So companies are doing important work.

    I also think there’s a huge difference—we obviously make all of our investments with a return-on-invested-capital perspective, but they also solve societal problems. And here are just three again from the list that I’m giving you a tease to. RapidSOS is kind of reinventing 911—literally saves lives by getting more accurate information more quickly to people in trouble. Obviously, as we move toward the future, energy is an important consideration. Radiant is an example from our energy portfolio that is doing very innovative work—kind of distributed, safe, clean energy. SHINE—a company with deep tech in the making of medical isotopes that go into healthcare, cancer treatment, and diagnosis—has big ambitions and big plans for the future. Again, where the alternatives are a long way away, and with half-lives, having things closer to the end user is very important. So we believe that doing well and doing good are aligned and not inconsistent.

    Speaker 1:
    So people ask—as we’ve shared the Apex 50, people have asked how we’ve selected. Again, we have 10 distributed teams. These teams have their own remit, have their own style, have their own vertical, and we worked together to bring them within the AV family. But they nominated, and then we debated, and we chose companies that we felt were doing well, meeting their benchmarks, and innovating. We’re looking at size of opportunity, execution, things on trend, diversity. We wanted to show the breadth and depth of the AV portfolio. And we thought that these companies again are ones that are noteworthy—to give a flavor of the kinds of companies we invest in. And at the end of the day, Mark Edwards, our CIO, and I made the final calls, and it was a vigorous process and debate. And then we look forward to doing it again next year.

    Again, just wanting to give a little sample even from the 50—here’s three companies: TTI in the quantum space, which has been really hot and interesting—kind of a very deep, long-term company we’re investing in. That is public—one can read about that, find analysts reviewing it. Groq obviously is a company we’re excited about that is really doing good work in inference. Oura rings—I mean, walk down the aisle of an airplane, you’re going to see ’em on many, many, many, many hands—many, many fingers. A company that probably has a lot of consumer recognition.

    Again, just a sample of the diversity—Bluesky and Sleeper. Bluesky is actually a company that came out of our blockchain team as a distributed, different stack strategy than X in the social media space. Sleeper is a company that we’ve been in for a while—actually going back to one of our earlier Green D investments—that has gone from its pre-seed stage to now is one of the leading players in fantasy sports. Very large, very successful. A16Z led the deal. So again, a little more visible there.

    So again, one of the things I’ll touch on too, which is—we have amazing companies within our portfolio that aren’t in this list. But at the end of the day, there was debate internally whether we should even put together a list like this, because inevitably there are going to be companies in the AV Apex 50 that stumble and don’t work out the way we hope. And then there are companies that aren’t on this list that are going to be legendary and do really well for themselves and our investors. But that’s what venture capital is about. It is a business where you have a point of view, you make decisions, and you live with the good ones and the bad ones. So we recognize that. And this is what we think today, and we’ll put together another list tomorrow. And again, it’s the fun, exciting, challenging, frustrating, rewarding part of being a venture capitalist.

    TTI, as an example I talked about, was a company we really love. But it has not always been an up-and-to-the-right experience. The company has struggled and had to make changes, and people became impatient, and really things were languishing—until they weren’t. And again, sometimes that is the nature of the beast here.

    We hope people check out the whole list. Again, I tried to tease it a little bit today, but I hope you give it a look and a scan. And again, we’re really proud of earning the right to be partners in these companies. Again, it is less than 5% of our portfolio, but these are companies that I think are noteworthy. So it’s really easy to check out the full report. We love to talk to people, so if anybody wants to chat about what we do and how we do it, encourage people to book a call with one of us. We love to tell our story.

    So thanks for your time today. I’m going to answer a few questions that have come in right now.

    So one of the questions that came in was: What industries or sectors are you seeing the most venture capital inflow? Besides AI, there is a lot of activity going on in energy. There’s a lot of activity going on in blockchain, obviously, and health tech. I would say those three are where we’re seeing some of the most exciting ventures being funded and a lot of activity going on.

    I think in the course of energy, I think everybody is familiar with the correlation between GDP and energy consumption. I think when you look at the development of a digital economy and an AI-centric economy, we need more energy. And so as a firm, we are in an “all of the above” category, with a special emphasis I think on kind of nuclear.

    We think that that is coming back—risk, reward, overall net benefit to society, our competitive position against China and other countries—it needs to happen. And so again, very proud of that. We have a long, deep, long-term commitment to all kinds of smart, new, innovative energy solutions.

    Health tech—huge part of the economy, huge part of society. We still are struggling with scourges of cancer, dementia, and other forms of health where I think there’s great promise combining new technologies and AI to transform longevity and health span. So those are two areas.

    And then again, I think this is a classic case of the hype cycle—ebb, flow—but the onward trend of innovation. We’re seeing that in blockchain. Just again, one real world—obviously Bitcoin is disrupting gold, I’ve written about that. I also see we’re seeing betting markets replace other types of markets that are far better predictors for outcomes than some old-world approaches like polls.

    I think with AI we’re going to continue to see huge innovation and necessity of the blockchain for authentication and security. So those three sectors I’d mention.

    What gives AV an edge over other venture firms? So number one, it is our network. If you’re an entrepreneur, when you raise money, clearly your most important decision is who’s going to lead your round of financing and what kind of deal they are going to provide.

    And then you’re going to round out your round of financing with other investors. We fit into the latter category. We don’t lead rounds, we don’t price rounds, we don’t negotiate terms. We evaluate those to determine whether we’re going to do a deal or not.

    But we fight for allocation by basically telling the entrepreneur—we’re going to do a small part of your round, we’re going to tuck in, and we’re going to be disproportionately helpful compared to our check size. And so that is the reason that we get in—because of our ability to help them make connections, introductions into potential customers, recruiting board members, just activating our network to help them build their business.

    Speaker 1:
    The core idea behind Alumni Ventures is that together we can do better in this asset class by pooling capital and pooling our ability to help than any of us could do on our own.

    How does AV manage exits? So I talked a little bit about how we get into deals and why we get into deals at such a good rate with these top-tier firms. On the exit side, it’s either really easy—meaning the company is just sold—or it can be tricky, in which case we have another investment committee and determine regularly how we’re going to sell stock.

    In an IPO, typically there’s a lockup and there are restrictions and volume considerations. And usually, we take a timed approach. So there are cases where we’re going to get out over a relatively short period of time.

    And then there’s other cases where we view the IPO as really a financing, and that we’re taking a more traditional long-term venture perspective, where we might sell our position over years—actually in a deep tech company or a biotech company—where we’re really just waiting to see the kind of venture returns and venture benchmarks and waypoints that we invested in with the company in the first case.

    So the quick line is: it’s easy if the company gets sold. If there’s a secondary opportunity or it’s a public company, we have a whole process that is usually based on time—that we’re going to just sell 10% of our position over the next 10 quarters, for example. But it’s really time-based, and we don’t tend to orient things like that.

    But I will also say it varies, and situations are unique. And we get in, and it’s always in the best interest of our investors.

    So happy to answer those questions. Again, encourage you to hop on the phone, talk with us, check out the Apex 50, and we’ll see you down the road. Thanks for your time.