The Deep Tech Frontier: 10 Game-Changing Companies

What Is Deep Tech?

Deep tech isn’t about incremental improvements — it’s about paradigm shifts. These companies are built on revolutionary scientific discoveries and advanced engineering principles, often merging expertise from multiple disciplines like physics, biology, and AI to tackle some of the world’s most complex challenges. Unlike traditional startups that refine existing technology, deep tech ventures forge entirely new capabilities, often requiring years of rigorous R&D before commercialization.

Some of today’s most transformative companies — like Apple, which redefined personal computing; and NVIDIA, whose GPUs fueled the AI boom — began as deep tech startups. Now a new wave of innovation is emerging, with developments in AI, quantum computing, and advanced materials reshaping industries at an unprecedented pace.

Why Deep Tech?

Deep tech doesn’t just disrupt industries, it reinvents them. These innovations are driving advancements in computing, healthcare, and sustainability, solving problems once thought insurmountable.

Now accounting for 20% of global venture funding, deep tech is widely recognized as a powerful driver of economic opportunity. The market is on a rapid growth trajectory, projected to soar from $150B in 2025 to $425B by 2034 at a 12% CAGR. As of January 2025, deep tech companies accounted for 25% of new unicorn startups, a significant increase from 2019. Combined with AI, these ventures now represent more than half of new unicorns.

Investing in deep tech isn’t just about advancing technology. It’s about backing the future’s most valuable enterprises.

Why Now?

Deep tech is no longer a vision of the future — it’s happening now.

We’re on the cusp of a tech revolution where venture capital is both an investment and an opportunity to shape the future.

Redefining the Future

The AV Deep Tech 10 showcases the transformative power of deep tech, driving breakthroughs in AI, quantum computing, biotechnology, and next-generation infrastructure. These companies are not only tackling some of the world’s most complex challenges but also reshaping industries and unlocking vast economic opportunities.

As deep tech innovation accelerates, Alumni Ventures remains dedicated to backing visionary founders and disruptive technologies that will define the future. From healthcare and computing to sustainable energy, the next wave of world-changing advancements is happening.

For more about AV’s Deep Tech Fund, please explore here.

This communication is from Alumni Ventures, a for-profit venture capital company that is not affiliated with or endorsed by any school. It is not personalized advice, and AV only provides advice to its client funds. This communication is neither an offer to sell, nor a solicitation of an offer to purchase, any security. Such offers are made only pursuant to the formal offering documents for the fund(s) concerned, and describe significant risks and other material information that should be carefully considered before investing. For additional information, please see here. Example portfolio companies are provided for illustrative purposes only and are not necessarily indicative of any AV fund or the outcomes experienced by any investor. Example portfolio companies shown are not available to future investors, except potentially in the case of follow-on investments. Venture capital investing involves substantial risk, including risk of loss of all capital invested. This communication includes forward-looking statements, generally consisting of any statement pertaining to any issue other than historical fact, including without limitation predictions, financial projections, the anticipated results of the execution of any plan or strategy, the expectation or belief of the speaker, or other events or circumstances to exist in the future. Forward-looking statements are not representations of actual fact, depend on certain assumptions that may not be realized, and are not guaranteed to occur. Any forward-looking statements included in this communication speak only as of the date of the communication. AV and its affiliates disclaim any obligation to update, amend, or alter such forward-looking statements, whether due to subsequent events, new information, or otherwise.

Co-investors are provided for illustrative purposes only, do not represent all organizations with which AV co-invests, and are not necessarily representative of future co-investors. The identity of a co-investor does not guarantee investment quality or performance.

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